CHIP Targets Toxic α-Synuclein Oligomers for Degradation

α-Synuclein (αSyn) can self-associate, forming oligomers, fibrils, and Lewy bodies, the pathological hallmark of Parkinson disease. Current dogma suggests that oligomeric αSyn intermediates may represent the most toxic αSyn species. Here, we studied the effect of a potent molecular chaperone, CHIP (...

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Bibliografiske detaljer
Main Authors: Tetzlaff, Julie E., Putcha, Preeti, Outeiro, Tiago F., Ivanov, Alexander, Berezovska, Oksana, Hyman, Bradley T., McLean, Pamela J.
Format: Artigo
Sprog:Inglês
Udgivet: 2008
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2936239/
https://ncbi.nlm.nih.gov/pubmed/18436529
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M802283200
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