Inhibition of dipeptidyl peptidase 8/9 impairs preadipocyte differentiation

por Han, Ruijun, Wang, Xinying, Bachovchin, William, Zukowska, Zofia, Osborn, John W.
Publicado no Sci Rep (2015)

α-Lytic protease can exist in two separately stable conformations with different His(57) mobilities and catalytic activities

por Haddad, Kristin Coffman, Sudmeier, James L., Bachovchin, Daniel A., Bachovchin, William W.
Publicado em 2005

Characterization of a single chain variable fragment of nivolumab that targets PD-1 and blocks PD-L1 binding

por Shin, Jong, Phelan, Paul J., Gjoerup, Ole, Bachovchin, William, Bullock, Peter A.
Publicado no Protein Expr Purif (2021)

GLP-1(32-36)amide Pentapeptide Increases Basal Energy Expenditure and Inhibits Weight Gain in Obese Mice

por Tomas, Eva, Stanojevic, Violeta, McManus, Karen, Khatri, Ashok, Everill, Paul, Bachovchin, William W., Habener, Joel F.
Publicado no Diabetes (2015)

Human FGF-21 Is a Substrate of Fibroblast Activation Protein

por Coppage, Andrew L., Heard, Kathryn R., DiMare, Matthew T., Liu, Yuxin, Wu, Wengen, Lai, Jack H., Bachovchin, William W.
Publicado no PLoS One (2016)

Analyses of the Interaction between the Origin Binding Domain from Simian Virus 40 T Antigen and Single-Stranded DNA Provide Insights into DNA Unwinding and Initiation of DNA Repli...

por Reese, Danielle K., Meinke, Gretchen, Kumar, Anuradha, Moine, Stephanie, Chen, Kathleen, Sudmeier, James L., Bachovchin, William, Bohm, Andrew, Bullock, Peter A.
Publicado em 2006

Circulating Fibroblast Activation Protein and Dipeptidyl Peptidase 4 in Rheumatoid Arthritis and Systemic Sclerosis

por Sinnathurai, Premarani, Lau, Wendy, de Ribeiro, Ana Julia Vieira, Bachovchin, William W, Englert, Helen, Howe, Graydon, Spencer, David, Manolios, Nicholas, Gorrell, Mark D.
Publicado no Int J Rheum Dis (2016)

HIV protease inhibitors block parasite signal peptide peptidases and prevent growth of Babesia microti parasites in erythrocytes

por Schwake, Christopher, Baldwin, Michael R., Bachovchin, William, Hegde, Shreeya, Schiemer, James, Okure, Carolyn, Levin, Andrew E., Vannier, Edouard, Hanada, Toshihiko, Chishti, Athar H.
Publicado no Biochem Biophys Res Commun (2019)

Tautomerism, acid-base equilibria, and H-bonding of the six histidines in subtilisin BPN′ by NMR

por Day, Regina M., Thalhauser, Craig J., Sudmeier, James L., Vincent, Matthew P., Torchilin, Ekaterina V., Sanford, David G., Bachovchin, Christopher W., Bachovchin, William W.
Publicado em 2003

Val-BoroPro Accelerates T Cell Priming via Modulation of Dendritic Cell Trafficking Resulting in Complete Regression of Established Murine Tumors

por Walsh, Meghaan P., Duncan, Brynn, Larabee, Shannon, Krauss, Aviva, Davis, Jessica P. E., Cui, Yongzhi, Kim, Su Young, Guimond, Martin, Bachovchin, William, Fry, Terry J.
Publicado em 2013

Unusual (1)H NMR chemical shifts support (His) C(ɛ)(1)—H⋅⋅⋅O⩵C H-bond: Proposal for reaction-driven ring flip mechanism in serine protease catalysis

por Ash, Elissa L., Sudmeier, James L., Day, Regina M., Vincent, Matthew, Torchilin, Ekaterina V., Haddad, Kristin Coffman, Bradshaw, Elizabeth M., Sanford, David G., Bachovchin, William W.
Publicado em 2000

Identification of Selective and Potent Inhibitors of Fibroblast Activation Protein and Prolyl Oligopeptidase

por Poplawski, Sarah E., Lai, Jack H., Li, Youhua, Jin, Zhiping, Liu, Yuxin, Wu, Wengen, Wu, Yong, Zhou, Yuhong, Sudmeier, James L., Sanford, David G., Bachovchin, William W.
Publicado em 2013

Fibroblast activation protein is dispensable for control of glucose homeostasis and body weight in mice

por Panaro, Brandon L., Coppage, Andrew L., Beaudry, Jacqueline L., Varin, Elodie M., Kaur, Kirandeep, Lai, Jack H., Wu, Wengen, Liu, Yuxin, Bachovchin, William W., Drucker, Daniel J.
Publicado no Mol Metab (2018)

Cleavage Specificity of Mycobacterium tuberculosis ClpP1P2 Protease and Identification of Novel Peptide Substrates and Boronate Inhibitors with Anti-bacterial Activity

por Akopian, Tatos, Kandror, Olga, Tsu, Christopher, Lai, Jack H., Wu, Wengen, Liu, Yuxin, Zhao, Peng, Park, Annie, Wolf, Lisa, Dick, Lawrence R., Rubin, Eric J., Bachovchin, William, Goldberg, Alfred L.
Publicado no J Biol Chem (2015)

A pan inhibitor of DASH family enzymes induces immunogenic modulation and sensitizes murine and human carcinoma cells to antigen-specific cytotoxic T lymphocyte killing: implicatio...

por Donahue, Renee N., Duncan, Brynn B., Fry, Terry J., Jones, Barry, Bachovchin, William W., Kiritsy, Christopher P., Lai, Jack H., Wu, Wengen, Zhao, Peng, Liu, Yuxin, Tsang, Kwong-Yok, Hodge, James W.
Publicado em 2014

A pan-inhibitor of DASH family enzymes induces immune-mediated regression of murine sarcoma and is a potent adjuvant to dendritic cell vaccination and adoptive T-cell therapy

por Duncan, Brynn B., Highfill, Steven L., Qin, Haiying, Bouchkouj, Najat, Larabee, Shannon, Zhao, Peng, Woznica, Iwona, Liu, Yuxin, Li, Youhua, Wu, Wengen, Lai, Jack H., Jones, Barry, Mackall, Crystal L., Bachovchin, William W., Fry, Terry J.
Publicado em 2013

Fibroblast Activation Protein (FAP) Accelerates Collagen Degradation and Clearance from Lungs in Mice

por Fan, Ming-Hui, Zhu, Qiang, Li, Hui-Hua, Ra, Hyun-Jeong, Majumdar, Sonali, Gulick, Dexter L., Jerome, Jacob A., Madsen, Daniel H., Christofidou-Solomidou, Melpo, Speicher, David W., Bachovchin, William W., Feghali-Bostwick, Carol, Puré, Ellen
Publicado no J Biol Chem (2016)

DPP8/9 inhibition induces pro-caspase-1-dependent monocyte and macrophage pyroptosis

por Okondo, Marian C., Johnson, Darren C., Sridharan, Ramya, Go, Eun Bin, Chui, Ashley J., Wang, Mitchell S., Poplawski, Sarah E., Wu, Wengen, Liu, Yuxin, Lai, Jack H., Sanford, David G., Arciprete, Michael O., Golub, Todd R., Bachovchin, William W., Bachovchin, Daniel A.
Publicado no Nat Chem Biol (2016)

A high-throughput, multiplexed assay for superfamily-wide profiling of enzyme activity

por Bachovchin, Daniel A., Koblan, Luke W., Wu, Wengen, Liu, Yuxin, Li, Youhua, Zhao, Peng, Woznica, Iwona, Shu, Ying, Lai, Jack H., Poplawski, Sarah E., Kiritsy, Christopher P., Healey, Sarah E., DiMare, Matthew, Sanford, David G., Munford, Robert S., Bachovchin, William W., Golub, Todd R.
Publicado no Nat Chem Biol (2014)

Quantitation of fibroblast activation protein (FAP)-specific protease activity in mouse, baboon and human fluids and organs()

por Keane, Fiona M., Yao, Tsun-Wen, Seelk, Stefanie, Gall, Margaret G., Chowdhury, Sumaiya, Poplawski, Sarah E., Lai, Jack H., Li, Youhua, Wu, Wengen, Farrell, Penny, Vieira de Ribeiro, Ana Julia, Osborne, Brenna, Yu, Denise M.T., Seth, Devanshi, Rahman, Khairunnessa, Haber, Paul, Topaloglu, A. Kemal, Wang, Chuanmin, Thomson, Sally, Hennessy, Annemarie, Prins, John, Twigg, Stephen M., McLennan, Susan V., McCaughan, Geoffrey W., Bachovchin, William W., Gorrell, Mark D.
Publicado em 2013