A pan inhibitor of DASH family enzymes induces immunogenic modulation and sensitizes murine and human carcinoma cells to antigen-specific cytotoxic T lymphocyte killing: implications for combination therapy with cancer vaccines

Recent studies have suggested that pan inhibitors of dipeptidyl peptidase-4 activity and/or structure homologs (DASH), including ARI-4175, can mediate tumor regression by immune-mediated mechanisms. This study assessed the potential of combining ARI-4175 with cancer vaccines. We evaluated ARI-4175&#...

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Detalhes bibliográficos
Main Authors: Donahue, Renee N., Duncan, Brynn B., Fry, Terry J., Jones, Barry, Bachovchin, William W., Kiritsy, Christopher P., Lai, Jack H., Wu, Wengen, Zhao, Peng, Liu, Yuxin, Tsang, Kwong-Yok, Hodge, James W.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4059051/
https://ncbi.nlm.nih.gov/pubmed/24731809
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.vaccine.2014.04.008
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