Human FGF-21 Is a Substrate of Fibroblast Activation Protein

FGF-21 is a key regulator of metabolism and potential drug candidate for the treatment of type II diabetes and other metabolic disorders. However, the half-life of active, circulating, human FGF-21 has recently been shown to be limited in mice and monkeys by a proteolytic cleavage between P171 and S...

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Bibliografske podrobnosti
izdano v:PLoS One
Main Authors: Coppage, Andrew L., Heard, Kathryn R., DiMare, Matthew T., Liu, Yuxin, Wu, Wengen, Lai, Jack H., Bachovchin, William W.
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2016
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4786124/
https://ncbi.nlm.nih.gov/pubmed/26962859
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0151269
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