Discovery of Novel Dual Inhibitors of the Wild-Type and the Most Prevalent Drug-Resistant Mutant, S31N, of the M2 Proton Channel from Influenza A Virus

Por Wang, Jizhou, Ma, Chunlong, Wang, Jun, Jo, Hyunil, Canturk, Belgin, Fiorin, Giacomo, Pinto, Lawrence H., Lamb, Robert A., Klein, Michael L., DeGrado, William F.
Publicado em 2013

Development of Dihydroxyphenyl Sulfonylisoindoline Derivatives as Liver-targeting Pyruvate Dehydrogenase Kinase Inhibitors

Por Tso, Shih-Chia, Lou, Mingliang, Wu, Cheng-Yang, Gui, Wen-Jun, Chuang, Jacinta L., Morlock, Lorraine K., Williams, Noelle S., Wynn, R. Max, Qi, Xiangbing, Chuang, David T.
Publicado no J Med Chem (2017)

A small molecule inhibitor that stabilizes the autoinhibited conformation of the oncogenic tyrosine phosphatase SHP2

Por Wu, Xiaoqin, Xu, Gang, Li, Xiaobo, Xu, Weiren, Li, Qianjin, Liu, Wei, Kirby, Karen A., Loh, Mignon L., Li, Jun, Sarafianos, Stefan G., Qu, Cheng-Kui
Publicado no J Med Chem (2018)

Structure-based design, synthesis, X-ray studies, and biological evaluation of novel HIV-1 protease inhibitors containing isophthalamide-derived P2-ligands

Por Ghosh, Arun K., Takayama, Jun, Kassekert, Luke A., Ella-Menye, Jean-Rene, Yashchuk, Sofiya, Agniswamy, Johnson, Wang, Yuan-Fang, Aoki, Manabu, Amano, Masayuki, Weber, Irene T., Mitsuya, Hiroaki
Publicado no Bioorg Med Chem Lett (2015)

Novel Diarylurea Based Allosteric Modulators of the Cannabinoid CB1 Receptor: Evaluation of Importance of 6-Pyrrolidinylpyridinyl Substitution

Por Nguyen, Thuy, German, Nadezhda, Decker, Ann M., Langston, Tiffany L., Gamage, Thomas F., Farquhar, Charlotte E., Li, Jun-Xu, Wiley, Jenny L., Thomas, Brian F., Zhang, Yanan
Publicado no J Med Chem (2017)

Design, synthesis, and cytotoxic activity of novel 7-substituted camptothecin derivatives incorporating piperazinyl-sulfonylamidine moieties

Por Yang, Cheng-Jie, Song, Zi-Long, Goto, Masuo, Liu, Ying-Qian, Hsieh, Kan-Yen, Morris-Natschke, Susan L., Zhao, Yong-Long, Zhang, Jun-Xiang, Lee, Kuo-Hsiung
Publicado no Bioorg Med Chem Lett (2017)

Derivatization of Agelastatin A Leading to Bioactive Analogs and a Trifunctional Probe

Por Jouanneau, Morgan, McClary, Brandon, Reyes, Jeremy C., Chen, Rong, Chen, Yuling, Plunkett, William, Cheng, Xin, Milinichik, Andrew Z., Albone, Earl F., Liu, Jun O., Romo, Daniel
Publicado no Bioorg Med Chem Lett (2016)

Discovery of a Phosphodiesterase 9A Inhibitor as a Potential Hypoglycemic Agent

Por Shao, Yong-xian, Huang, Manna, Cui, Wenjun, Feng, Ling-Jun, Wu, Yinuo, Cai, Yinghong, Li, Zhe, Zhu, Xinhai, Liu, Peiqing, Wan, Yiqian, Ke, Hengming, Luo, Hai-Bin
Publicado no J Med Chem (2014)

Pyridinylpyrimidines selectively inhibit human methionine aminopeptidase-1()

Por Zhang, Pengtao, Yang, Xinye, Zhang, Feiran, Gabelli, Sandra B., Wang, Renxiao, Zhang, Yihua, Bhat, Shridhar, Chen, Xiaochun, Furlani, Manuel, Amzel, L. Mario, Liu, Jun O., Ma, Dawei
Publicado em 2013

1α,25-Dihydroxyvitamin D(3)-26,23-lactam analogues function as vitamin D receptor antagonists in human and rodent cells

Por Ishizuka, Seiichi, Kurihara, Noriyoshi, Hiruma, Yuko, Miura, Daishiro, Namekawa, Jun-ichi, Tamura, Azusa, Kato-Nakamura, Yuko, Nakano, Yusuke, Takenouchi, Kazuya, Hashimoto, Yuichi, Nagasawa, Kazuo, Roodman, G. David
Publicado em 2008

Indolinyl-Thiazole Based Inhibitors of Scavenger Receptor-BI (SR-BI)-Mediated Lipid Transport

Por Dockendorff, Chris, Faloon, Patrick W., Yu, Miao, Youngsaye, Willmen, Penman, Marsha, Nieland, Thomas J. F., Nag, Partha P., Lewis, Timothy A., Pu, Jun, Bennion, Melissa, Negri, Joseph, Paterson, Conor, Lam, Garrett, Dandapani, Sivaraman, Perez, José R., Munoz, Benito, Palmer, Michelle A., Schreiber, Stuart L., Krieger, Monty
Publicado no ACS Med Chem Lett (2015)

Discovery of Clinical Candidate BMS-823778 as an Inhibitor of Human 11β-Hydroxysteroid Dehydrogenase Type 1 (11β-HSD-1)

Por Li, Jun, Kennedy, Lawrence J., Walker, Steven J., Wang, Haixia, Li, James J., Hong, Zhenqiu, O’Connor, Stephen P., Ye, Xiang-yang, Chen, Stephanie, Wu, Shung, Yoon, David S., Nayeem, Akbar, Camac, Daniel M., Ramamurthy, Vidhyashankar, Morin, Paul E., Sheriff, Steven, Wang, Mengmeng, Harper, Timothy W., Golla, Rajasree, Seethala, Ramakrishna, Harrity, Thomas, Ponticiello, Randolph P., Morgan, Nathan N., Taylor, Joseph R., Zebo, Rachel, Maxwell, Brad, Moulin, Frederick, Gordon, David A., Robl, Jeffrey A.
Publicado no ACS Med Chem Lett (2018)

Design and Synthesis of N(6)-Substituted-4′-thioadenosine-5′-uronamides As Potent and Selective Human A(3) Adenosine Receptor Agonists

Por Choi, Won Jun, Lee, Hyuk Woo, Kim, Hea Ok, Chinn, Moshe, Gao, Zhan-Guo, Patel, Amit, Jacobson, Kenneth A., Moon, Hyung Ryong, Jung, Young Hoon, Jeong, Lak Shin
Publicado em 2009

3-Azatetracyclo[5.2.1.1(5,8).0(1,5)]undecane derivatives: from wild-type inhibitors of the M2 ion channel of influenza A virus to derivatives with potent activity against the V27A...

Por Rey-Carrizo, Matias, Torres, Eva, Ma, Chunlong, Barniol-Xicota, Marta, Wang, Jun, Wu, Yibing, Naesens, Lieve, DeGrado, William F., Lamb, Robert A., Pinto, Lawrence H., Vázquez, Santiago
Publicado em 2013

IVSPlat 1.0: an integrated virtual screening platform with a molecular graphical interface

Por Sun, Yin Xue, Huang, Yan Xin, Li, Feng Li, Wang, Hong Yan, Fan, Cong, Bao, Yong Li, Sun, Lu Guo, Ma, Zhi Qiang, Kong, Jun, Li, Yu Xin
Publicado em 2012

Discovery of Disubstituted Imidazo[4,5-b]pyridines and Purines as Potent TrkA Inhibitors

Por Wang, Tao, Lamb, Michelle L., Block, Michael H., Davies, Audrey Molina, Han, Yongxin, Hoffmann, Ethan, Ioannidis, Stephanos, Josey, John A., Liu, Zhong-Ying, Lyne, Paul D., MacIntyre, Terry, Mohr, Peter J., Omer, Charles A., Sjögren, Tove, Thress, Kenneth, Wang, Bin, Wang, Haiyun, Yu, Dingwei, Zhang, Hai-Jun
Publicado em 2012

Synthesis, pharmacology and preclinical evaluation of (11)C-labeled 1,3-dihydro-2H-benzo[d]imidazol-2-ones for imaging γ8-dependent transmembrane AMPA receptor regulatory protein

Por Chen, Zhen, Mori, Wakana, Zhang, Xiaofei, Yamasaki, Tomoteru, Dunn, Patrick J., Zhang, Genwei, Fu, Hualong, Shao, Tuo, Zhang, Yiding, Hatori, Akiko, Ma, Longle, Fujinaga, Masayuki, Xie, Lin, Deng, Xiaoyun, Li, Hua, Yu, Qingzhen, Rong, Jian, Josephson, Lee, Ma, Jun-An, Shao, Yihan, Tomita, Susumu, Zhang, Ming-Rong, Liang, Steven H.
Publicado no Eur J Med Chem (2018)

Syntheses, Neural Protective Activities, and Inhibition of Glycogen Synthase Kinase-3β of Substituted Quinolines

Por Lu, Jianyu, Maezawa, Izumi, Weerasekara, Sahani, Erenler, Ramazan, Nguyen, Tuyen D. T., Nguyen, James, Swisher, Luxi Z., Li, Jun, Jin, Lee-Way, Ranjan, Alok, Srivastava, Sanjay K., Hua, Duy H.
Publicado em 2014

Design of novel HIV-1 protease inhibitors incorporating isophthalamide-derived P2-P3 ligands: synthesis, biological evaluation and X-ray structural studies of inhibitor-HIV-1 prote...

Por Ghosh, Arun K., Brindisi, Margherita, Nyalapatla, Prasanth R., Takayama, Jun, Ella-Menye, Jean-Rene, Yashchuk, Sofiya, Agniswamy, Johnson, Wang, Yuan-Fang, Aoki, Manabu, Amano, Masayuki, Weber, Irene T., Mitsuya, Hiroaki
Publicado no Bioorg Med Chem (2017)

Apogossypol Derivatives as Pan-active Inhibitors of Anti-apoptotic B-cell lymphoma/leukemia-2 (Bcl-2) Family Proteins

Por Wei, Jun, Kitada, Shinichi, Rega, Michele F., Stebbins, John L., Zhai, Dayong, Cellitti, Jason, Yuan, Hongbin, Emdadi, Aras, Dahl, Russell, Zhang, Ziming, Yang, Li, Reed, John C., Pellecchia, Maurizio
Publicado em 2009