Editorial of Special Column “Research on Emerging COVID-19 (Target, Mechanism, and Therapeutics)”

per Luo, Hai-Bin, Chen, Shilin, Liu, Peiqing
Publicat a Acta Pharm Sin B (2020)

Catalytic Roles of Coenzyme Pyridoxal-5′-phosphate (PLP) in PLP-dependent Enzymes: Reaction Pathway for Methionine-γ-lyase-catalyzed L-methionine Depletion

per Li, Zhe, Zhao, Yunsong, Zhou, Huifang, Luo, Hai-Bin, Zhan, Chang-Guo
Publicat a ACS Catal (2020)

Structural Asymmetry of Phosphodiesterase-9, Potential Protonation of a Glutamic Acid, and Role of the Invariant Glutamine

per Hou, Jing, Xu, Jie, Liu, Ming, Zhao, Ruizhi, Luo, Hai-Bin, Ke, Hengming
Publicat 2011

Computational Design of a Time-Dependent Histone Deacetylase 2 Selective Inhibitor

per Zhou, Jingwei, Li, Min, Chen, Nanhao, Wang, Shenglong, Luo, Hai-Bin, Zhang, Yingkai, Wu, Ruibo
Publicat a ACS Chem Biol (2014)

Six New Tetraprenylated Alkaloids from the South China Sea Gorgonian Echinogorgia pseudossapo

per Sun, Zhang-Hua, Cai, Ying-Hong, Fan, Cheng-Qi, Tang, Gui-Hua, Luo, Hai-Bin, Yin, Sheng
Publicat 2014

Discovery of novel PDE9 inhibitors capable of inhibiting Aβ aggregation as potential candidates for the treatment of Alzheimer’s disease

per Su, Tao, Zhang, Tianhua, Xie, Shishun, Yan, Jun, Wu, Yinuo, Li, Xingshu, Huang, Ling, Luo, Hai-Bin
Publicat a Sci Rep (2016)

Structure-Based Design, Synthesis, Biological Evaluation, and Molecular Docking of Novel PDE10 Inhibitors With Antioxidant Activities

per Li, Jinxuan, Chen, Jing-Yi, Deng, Ya-Lin, Zhou, Qian, Wu, Yinuo, Wu, Deyan, Luo, Hai-Bin
Publicat a Front Chem (2018)

Reply to Ma and Wang: Reliability of various in vitro activity assays on SARS-CoV-2 main protease inhibitors

per Li, Zhe, Lin, Yuxi, Huang, Yi-You, Liu, Runduo, Zhan, Chang-Guo, Wang, Xin, Luo, Hai-Bin
Publicat a Proc Natl Acad Sci U S A (2021)

Discovery of novel PDE9A inhibitors with antioxidant activities for treatment of Alzheimer’s disease

per Zhang, Chen, Zhou, Qian, Wu, Xu-Nian, Huang, Ya-Dan, Zhou, Jie, Lai, Zengwei, Wu, Yinuo, Luo, Hai-Bin
Publicat a J Enzyme Inhib Med Chem (2017)

Biophysical analysis of the putative acetyltransferase SACOL2570 from methicillin-resistant Staphylococcus aureus

per Luo, Hai-Bin, Knapik, Aleksandra A., Petkowski, Janusz J., Demas, Matthew, Shumilin, Igor A., Zheng, Heping, Chruszcz, Maksymilian, Minor, Wladek
Publicat 2013

Crystal structure and molecular modeling study of N-carbamoylsarcosine amidase Ta0454 from Thermoplasma acidophilum

per Luo, Hai-Bin, Zheng, Heping, Zimmerman, Matthew D., Chruszcz, Maksymilian, Skarina, Tatiana, Egorova, Olga, Savchenko, Alexei, Edwards, Aled M., Minor, Wladek
Publicat 2009

Structure-based design, synthesis, and biological evaluation of novel pyrimidinone derivatives as PDE9 inhibitors

per Wu, Xu-Nian, Huang, Ya-Dan, Li, Jin-Xuan, Yu, Yan-Fa, Qian, Zhou, Zhang, Chen, Wu, Yinuo, Luo, Hai-Bin
Publicat a Acta Pharm Sin B (2018)

Nobiletin and its derivatives overcome multidrug resistance (MDR) in cancer: total synthesis and discovery of potent MDR reversal agents

per Feng, Senling, Zhou, Huifang, Wu, Deyan, Zheng, Dechong, Qu, Biao, Liu, Ruiming, Zhang, Chen, Li, Zhe, Xie, Ying, Luo, Hai-Bin
Publicat a Acta Pharm Sin B (2020)

Ginsenoside Rg5 overcomes chemotherapeutic multidrug resistance mediated by ABCB1 transporter: in vitro and in vivo study

per Feng, Sen-Ling, Luo, Hai-Bin, Cai, Liang, Zhang, Jie, Wang, Dan, Chen, Ying-Jiang, Zhan, Huan-Xing, Jiang, Zhi-Hong, Xie, Ying
Publicat a J Ginseng Res (2020)

Enzymatic activity characterization of SARS coronavirus 3C-like protease by fluorescence resonance energy transfer technique

per Chen, Shuai, Chen, Li-li, Luo, Hai-bin, Sun, Tao, Chen, Jing, Ye, Fei, Cai, Jian-hua, Shen, Jing-kang, Shen, Xu, Jiang, Hua-liang
Publicat a Acta Pharmacol Sin (2005)

Discovery of highly selective and orally available benzimidazole-based phosphodiesterase 10 inhibitors with improved solubility and pharmacokinetic properties for treatment of pulm...

per Yang, Yuncong, Zhang, Sirui, Zhou, Qian, Zhang, Chen, Gao, Yuqi, Wang, Hao, Li, Zhe, Wu, Deyan, Wu, Yinuo, Huang, Yi-You, Guo, Lei, Luo, Hai-Bin
Publicat a Acta Pharm Sin B (2020)

Discovery of a Phosphodiesterase 9A Inhibitor as a Potential Hypoglycemic Agent

per Shao, Yong-xian, Huang, Manna, Cui, Wenjun, Feng, Ling-Jun, Wu, Yinuo, Cai, Yinghong, Li, Zhe, Zhu, Xinhai, Liu, Peiqing, Wan, Yiqian, Ke, Hengming, Luo, Hai-Bin
Publicat a J Med Chem (2014)

Structural Asymmetry of Phosphodiesterase-9A and a Unique Pocket for Selective Binding of a Potent Enantiomeric Inhibitor

per Huang, Manna, Shao, Yongxian, Hou, Jianying, Cui, Wenjun, Liang, Beibei, Huang, Yingchun, Li, Zhe, Wu, Yinuo, Zhu, Xinhai, Liu, Peiqing, Wan, Yiqian, Ke, Hengming, Luo, Hai-Bin
Publicat a Mol Pharmacol (2015)

C33(S), a novel PDE9A inhibitor, protects against rat cardiac hypertrophy through upregulating cGMP signaling

per Wang, Pan-xia, Li, Zhuo-ming, Cai, Si-dong, Li, Jing-yan, He, Ping, Huang, Yi, Feng, Guo-shuai, Luo, Hai-bin, Chen, Shao-rui, Liu, Pei-qing
Publicat a Acta Pharmacol Sin (2017)

Structure-based discovery of highly selective phosphodiesterase-9A inhibitors and implications for inhibitor design

per Meng, Fei, Hou, Jing, Shao, Yong-Xian, Wu, Pei-Ying, Huang, Manna, Zhu, Xinhai, Cai, Yonghong, Li, Zhe, Xu, Jie, Liu, Peiqing, Luo, Hai-Bin, Wan, Yiqian, Ke, Hengming
Publicat 2012