Nobiletin and its derivatives overcome multidrug resistance (MDR) in cancer: total synthesis and discovery of potent MDR reversal agents

Our recent studies demonstrated that the natural product nobiletin (NOB) served as a promising multidrug resistance (MDR) reversal agent and improved the effectiveness of cancer chemotherapy in vitro. However, low aqueous solubility and difficulty in total synthesis limited its application as a ther...

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Detalhes bibliográficos
Publicado no:Acta Pharm Sin B
Main Authors: Feng, Senling, Zhou, Huifang, Wu, Deyan, Zheng, Dechong, Qu, Biao, Liu, Ruiming, Zhang, Chen, Li, Zhe, Xie, Ying, Luo, Hai-Bin
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2020
Assuntos:
Original article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7016283/
https://ncbi.nlm.nih.gov/pubmed/32082977
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.apsb.2019.07.007
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