Discovery of Potent and Reversible Monoacylglycerol Lipase Inhibitors

Monoacylglycerol lipase (MGL) is a serine hydrolase involved in the biological deactivation of the endocannabinoid 2-arachidonoyl-sn-glycerol (2-AG). Previous efforts to design MGL inhibitors have focused on chemical scaffolds that irreversibly block the activity of this enzyme. Here, we describe tw...

Celý popis

Uloženo v:
Podrobná bibliografie
Hlavní autoři: King, Alvin R., Dotsey, Emmanuel Y., Lodola, Alessio, Jung, Kwang Mook, Ghomian, Azar, Qiu, Yan, Fu, Jin, Mor, Marco, Piomelli, Daniele
Médium: Artigo
Jazyk:Inglês
Vydáno: 2009
Témata:
Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3034734/
https://ncbi.nlm.nih.gov/pubmed/19875078
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2009.09.012
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky