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Discovery of Potent and Reversible Monoacylglycerol Lipase Inhibitors
Monoacylglycerol lipase (MGL) is a serine hydrolase involved in the biological deactivation of the endocannabinoid 2-arachidonoyl-sn-glycerol (2-AG). Previous efforts to design MGL inhibitors have focused on chemical scaffolds that irreversibly block the activity of this enzyme. Here, we describe tw...
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| Autori principali: | , , , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2009
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3034734/ https://ncbi.nlm.nih.gov/pubmed/19875078 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2009.09.012 |
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