URB602 Inhibits Monoacylglycerol Lipase and Selectively Blocks 2-Arachidonoylglycerol Degradation in Intact Brain Slices

The N-aryl carbamate URB602 (biphenyl-3-ylcarbamic acid cyclohexyl ester) is an inhibitor of monoacylglycerol lipase (MGL), a serine hydrolase involved in the biological deactivation of the endocannabinoid 2-arachidonoyl-sn-glycerol (2-AG). Here, we investigated the mechanism by which URB602 inhibit...

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Detalhes bibliográficos
Main Authors: King, Alvin R., Duranti, Andrea, Tontini, Andrea, Rivara, Silvia, Rosengarth, Anja, Clapper, Jason R., Astarita, Giuseppe, Geaga, Jennifer A., Luecke, Hartmut, Mor, Marco, Tarzia, Giorgio, Piomelli, Daniele
Formato: Artigo
Idioma:Inglês
Publicado em: 2007
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2225625/
https://ncbi.nlm.nih.gov/pubmed/18096504
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2007.10.017
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