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Synthesis and characterization of a peripherally restricted CB(1) cannabinoid antagonist, URB447, that reduces feeding and body-weight gain in mice

Cannabinoid CB(1) receptor antagonists reduce body weight in rodents and humans, but their clinical utility as anti-obesity agents is limited by centrally mediated side effects. Here, we describe the first mixed CB(1) antagonist/CB(2) agonist, URB447 ([4-amino-1-(4-chlorobenzyl)-2-methyl-5-phenyl-1H...

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Hlavní autoři: LoVerme, Jesse, Duranti, Andrea, Tontini, Andrea, Spadoni, Gilberto, Mor, Marco, Rivara, Silvia, Stella, Nephi, Xu, Cong, Tarzia, Giorgio, Piomelli, Daniele
Médium: Artigo
Jazyk:Inglês
Vydáno: 2008
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3690177/
https://ncbi.nlm.nih.gov/pubmed/19128970
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2008.12.059
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