Pharmacokinetics, pharmacodynamics and safety studies on URB937, a peripherally restricted fatty acid amide hydrolase inhibitor, in rats

OBJECTIVES: URB937, a peripheral fatty acid amide hydrolase (FAAH) inhibitor, exerts profound analgesic effects in animal models. We examined, in rats, (1) the pharmacokinetic profile of oral URB937; (2) the compound's ability to elevate levels of the representative FAAH substrate, oleoylethano...

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Publicat a:J Pharm Pharmacol
Autors principals: Vozella, Valentina, Ahmed, Faizy, Choobchian, Paoula, Merrill, Collin B, Zibardi, Cristina, Tarzia, Giorgio, Mor, Marco, Duranti, Andrea, Tontini, Andrea, Rivara, Silvia, Piomelli, Daniele
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2019
Matèries:
Research Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6842052/
https://ncbi.nlm.nih.gov/pubmed/31579946
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jphp.13166
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