Discovery of a Phosphodiesterase 9A Inhibitor as a Potential Hypoglycemic Agent

[Image: see text] Phosphodiesterase 9 (PDE9) inhibitors have been studied as potential therapeutics for treatment of diabetes and Alzheimer’s disease. Here we report a potent PDE9 inhibitor 3r that has an IC(50) of 0.6 nM and >150-fold selectivity over other PDEs. The HepG2 cell-based assay shows...

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Detalhes bibliográficos
Publicado no:J Med Chem
Main Authors: Shao, Yong-xian, Huang, Manna, Cui, Wenjun, Feng, Ling-Jun, Wu, Yinuo, Cai, Yinghong, Li, Zhe, Zhu, Xinhai, Liu, Peiqing, Wan, Yiqian, Ke, Hengming, Luo, Hai-Bin
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2014
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4281101/
https://ncbi.nlm.nih.gov/pubmed/25432025
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm500836h
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