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Refolding and kinetic characterization of the phosphodiesterase-8A catalytic domain

Cyclic nucleotide phosphodiesterase-8 (PDE8) hydrolyzes the second messenger cAMP and is involved in many biological processes such as testosterone production. Although the bacterial and mammalian expression systems have been extensively tried, production of large quantity of soluble and active PDE8...

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Autori principali: Yan, Zier, Wang, Huanchen, Cai, Jiwen, Ke, Hengming
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2008
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2677826/
https://ncbi.nlm.nih.gov/pubmed/18984055
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.pep.2008.10.005
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