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Kinetic and structural studies of phosphodiesterase-8A and implication on the inhibitor selectivity
Cyclic nucleotide phosphodiesterase-8 (PDE8) is a family of cAMP-specific enzymes and plays important roles in many biological processes, including T-cell activation, testosterone production, adrenocortical hyperplasia, and thyroid function. However, no PDE8 selective inhibitors are available for tr...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2646200/ https://ncbi.nlm.nih.gov/pubmed/18983167 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi801487x |
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