Structures of the four subfamilies of phosphodiesterase-4 provide insight into the selectivity of their inhibitors

PDE4 (phosphodiesterase-4)-selective inhibitors have attracted much attention as potential therapeutics for the treatment of both depression and major inflammatory diseases, but their practical application has been compromised by side effects. A possible cause for the side effects is that current PD...

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Detalhes bibliográficos
Main Authors: Wang, Huanchen, Peng, Ming-Sheng, Chen, Yi, Geng, Jie, Robinson, Howard, Houslay, Miles D., Cai, Jiwen, Ke, Hengming
Formato: Artigo
Idioma:Inglês
Publicado em: Portland Press Ltd. 2007
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2267353/
https://ncbi.nlm.nih.gov/pubmed/17727341
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20070970
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