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Insight into binding of phosphodiesterase-9A selective inhibitors by crystal structures and mutagenesis
PDE9 inhibitors have been studied as therapeutics for treatment of cardiovascular diseases, diabetes, and neurodegenerative disorders. To illustrate the inhibitor selectivity, the crystal structures of the PDE9A catalytic domain in complex with the enantiomers of PDE9 inhibitor 1-(2-chlorophenyl)-6-...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2831206/ https://ncbi.nlm.nih.gov/pubmed/20121115 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm901519f |
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