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Structural insight into substrate specificity of phosphodiesterase 10

Phosphodiesterases (PDEs) hydrolyze the second messengers cAMP and cGMP. It remains unknown how individual PDE families selectively recognize cAMP and cGMP. This work reports structural studies on substrate specificity. The crystal structures of the catalytic domains of the D674A and D564N mutants o...

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Main Authors: Wang, Huanchen, Liu, Yudong, Hou, Jing, Zheng, Meiyan, Robinson, Howard, Ke, Hengming
格式: Artigo
語言:Inglês
出版: National Academy of Sciences 2007
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC1851569/
https://ncbi.nlm.nih.gov/pubmed/17389385
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0700279104
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