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Structural insight into substrate specificity of phosphodiesterase 10
Phosphodiesterases (PDEs) hydrolyze the second messengers cAMP and cGMP. It remains unknown how individual PDE families selectively recognize cAMP and cGMP. This work reports structural studies on substrate specificity. The crystal structures of the catalytic domains of the D674A and D564N mutants o...
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| Autores principales: | , , , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
National Academy of Sciences
2007
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1851569/ https://ncbi.nlm.nih.gov/pubmed/17389385 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0700279104 |
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