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An insight into the pharmacophores of phosphodiesterase-5 inhibitors from synthetic and crystal structural studies
Selective inhibitors of cyclic nucleotide phosphodiesterase-5 (PDE5) have been used as drugs for treatment of male erectile dysfunction and pulmonary hypertension. An insight into the pharmacophores of PDE5 inhibitors is essential for development of second generation of PDE5 inhibitors, but has not...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2409583/ https://ncbi.nlm.nih.gov/pubmed/18346713 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcp.2008.01.019 |
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