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Refolding and kinetic characterization of the phosphodiesterase-8A catalytic domain
Cyclic nucleotide phosphodiesterase-8 (PDE8) hydrolyzes the second messenger cAMP and is involved in many biological processes such as testosterone production. Although the bacterial and mammalian expression systems have been extensively tried, production of large quantity of soluble and active PDE8...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2677826/ https://ncbi.nlm.nih.gov/pubmed/18984055 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.pep.2008.10.005 |
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