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Structural Asymmetry of Phosphodiesterase-9A and a Unique Pocket for Selective Binding of a Potent Enantiomeric Inhibitor

Phosphodiesterase-9 (PDE9) inhibitors have been studied as potential therapeutics for treatment of central nervous system diseases and diabetes. Here, we report the discovery of a new category of PDE9 inhibitors by rational design on the basis of the crystal structures. The best compound, (S)-6-((1-...

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Detalhes bibliográficos
Publicado no:Mol Pharmacol
Main Authors: Huang, Manna, Shao, Yongxian, Hou, Jianying, Cui, Wenjun, Liang, Beibei, Huang, Yingchun, Li, Zhe, Wu, Yinuo, Zhu, Xinhai, Liu, Peiqing, Wan, Yiqian, Ke, Hengming, Luo, Hai-Bin
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Pharmacology and Experimental Therapeutics 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4613944/
https://ncbi.nlm.nih.gov/pubmed/26316540
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.115.099747
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