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Structural Asymmetry of Phosphodiesterase-9A and a Unique Pocket for Selective Binding of a Potent Enantiomeric Inhibitor
Phosphodiesterase-9 (PDE9) inhibitors have been studied as potential therapeutics for treatment of central nervous system diseases and diabetes. Here, we report the discovery of a new category of PDE9 inhibitors by rational design on the basis of the crystal structures. The best compound, (S)-6-((1-...
में बचाया:
में प्रकाशित: | Mol Pharmacol |
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मुख्य लेखकों: | , , , , , , , , , , , , |
स्वरूप: | Artigo |
भाषा: | Inglês |
प्रकाशित: |
The American Society for Pharmacology and Experimental Therapeutics
2015
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विषय: | |
ऑनलाइन पहुंच: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4613944/ https://ncbi.nlm.nih.gov/pubmed/26316540 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.115.099747 |
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