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Design and Synthesis of Potent and Selective PIM Kinase Inhibitors by Targeting Unique Structure of ATP-Binding Pocket
[Image: see text] In the development of kinase inhibitors, one of the major concerns is selectivity. An effective strategy to achieve high selectivity is to utilize structural differences among kinases to inform inhibitor design. Here, we set out to improve the PIM (proviral integration site for Mol...
Sparad:
| I publikationen: | ACS Med Chem Lett |
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| Huvudupphovsmän: | , , , , |
| Materialtyp: | Artigo |
| Språk: | Inglês |
| Publicerad: |
American Chemical
Society
2017
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| Länkar: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5430388/ https://ncbi.nlm.nih.gov/pubmed/28523101 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.6b00518 |
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