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Design and Synthesis of Potent and Selective PIM Kinase Inhibitors by Targeting Unique Structure of ATP-Binding Pocket
[Image: see text] In the development of kinase inhibitors, one of the major concerns is selectivity. An effective strategy to achieve high selectivity is to utilize structural differences among kinases to inform inhibitor design. Here, we set out to improve the PIM (proviral integration site for Mol...
Kaydedildi:
| Yayımlandı: | ACS Med Chem Lett |
|---|---|
| Asıl Yazarlar: | , , , , |
| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
American Chemical
Society
2017
|
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5430388/ https://ncbi.nlm.nih.gov/pubmed/28523101 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.6b00518 |
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