Structural analysis of PIM1 kinase complexes with ATP-competitive inhibitors

PIM1 is an oncogenic kinase overexpressed in a number of cancers where it correlates with poor prognosis. Several studies demonstrated that inhibition of PIM1 activity is an attractive strategy in fighting overexpressing cancers, while distinct structural features of ATP binding pocket make PIM1 an...

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Pubblicato in:Sci Rep
Autori principali: Bogusz, Jozefina, Zrubek, Karol, Rembacz, Krzysztof P., Grudnik, Przemyslaw, Golik, Przemyslaw, Romanowska, Malgorzata, Wladyka, Benedykt, Dubin, Grzegorz
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2017
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5645348/
https://ncbi.nlm.nih.gov/pubmed/29042609
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-13557-z
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