Crystal structure of a low molecular weight activator Blm-pep with yeast 20S proteasome – insights into the enzyme activation mechanism

Proteasomes are responsible for protein turnover in eukaryotic cells, degrading short-lived species but also removing improperly folded or oxidatively damaged ones. Dysfunction of a proteasome results in gradual accumulation of misfolded/damaged proteins, leading to their aggregation. It has been po...

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Bibliographic Details
Published in:Sci Rep
Main Authors: Witkowska, Julia, Giżyńska, Małgorzata, Grudnik, Przemysław, Golik, Przemysław, Karpowicz, Przemysław, Giełdoń, Artur, Dubin, Grzegorz, Jankowska, Elżbieta
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2017
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5522460/
https://ncbi.nlm.nih.gov/pubmed/28733623
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-05997-4
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