Proline- and Arginine-Rich Peptides as Flexible Allosteric Modulators of Human Proteasome Activity

[Image: see text] Proline- and arginine-rich peptide PR11 is an allosteric inhibitor of 20S proteasome. We modified its sequence inter alia by introducing HbYX, RYX, or RHbX C-terminal extensions (Hb, hydrophobic moiety; R, arginine; Y, tyrosine; X, any residue). Consequently, we were able to improv...

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Detalhes bibliográficos
Publicado no:J Med Chem
Main Authors: Giżyńska, Małgorzata, Witkowska, Julia, Karpowicz, Przemysław, Rostankowski, Rafał, Chocron, Estrella S., Pickering, Andrew M., Osmulski, Pawel, Gaczynska, Maria, Jankowska, Elżbieta
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2018
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6796967/
https://ncbi.nlm.nih.gov/pubmed/30452262
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.8b01025
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