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Proline- and Arginine-Rich Peptides as Flexible Allosteric Modulators of Human Proteasome Activity
[Image: see text] Proline- and arginine-rich peptide PR11 is an allosteric inhibitor of 20S proteasome. We modified its sequence inter alia by introducing HbYX, RYX, or RHbX C-terminal extensions (Hb, hydrophobic moiety; R, arginine; Y, tyrosine; X, any residue). Consequently, we were able to improv...
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| Veröffentlicht in: | J Med Chem |
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| Hauptverfasser: | , , , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
American Chemical
Society
2018
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| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6796967/ https://ncbi.nlm.nih.gov/pubmed/30452262 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.8b01025 |
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