Structural analysis of PIM1 kinase complexes with ATP-competitive inhibitors

PIM1 is an oncogenic kinase overexpressed in a number of cancers where it correlates with poor prognosis. Several studies demonstrated that inhibition of PIM1 activity is an attractive strategy in fighting overexpressing cancers, while distinct structural features of ATP binding pocket make PIM1 an...

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Udgivet i:Sci Rep
Main Authors: Bogusz, Jozefina, Zrubek, Karol, Rembacz, Krzysztof P., Grudnik, Przemyslaw, Golik, Przemyslaw, Romanowska, Malgorzata, Wladyka, Benedykt, Dubin, Grzegorz
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5645348/
https://ncbi.nlm.nih.gov/pubmed/29042609
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-13557-z
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