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Computational Design of a Time-Dependent Histone Deacetylase 2 Selective Inhibitor
[Image: see text] Development of isoform-selective histone deacetylase (HDAC) inhibitors is of great biological and medical interest. Among 11 zinc-dependent HDAC isoforms, it is particularly challenging to achieve isoform inhibition selectivity between HDAC1 and HDAC2 due to their very high structu...
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| Publicado no: | ACS Chem Biol |
|---|---|
| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American
Chemical Society
2014
|
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4372102/ https://ncbi.nlm.nih.gov/pubmed/25546141 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cb500767c |
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