Llwytho...

Discovery of histone deacetylase 8 selective inhibitors

We have developed an efficient method for synthesizing candidate histone deacetylase (HDAC) inhibitors in 96-well plates, which are used directly in high-throughput screening. We selected building blocks having hydrazide, aldehyde and hydroxamic acid functionalities. The hydrazides were coupled with...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Tang, Weiping, Luo, Tuoping, Greenberg, Edward F., Bradner, James E., Schreiber, Stuart L.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2011
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3403710/
https://ncbi.nlm.nih.gov/pubmed/21334896
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2011.01.134
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