Identification and Characterization of Small Molecule Inhibitors of a Class I Histone Deacetylase from Plasmodium falciparum

[Image: see text] A library of approximately 2000 small molecules biased toward inhibition of histone deacetylases was assayed for antimalarial activity in a high-throughput P. falciparum viability assay. Active compounds were cross-analyzed for induction of histone hyperacetylation in a human myelo...

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Autors principals: Patel, Vishal, Mazitschek, Ralph, Coleman, Bradley, Nguyen, Cokey, Urgaonkar, Sameer, Cortese, Joseph, Barker, Robert H., Greenberg, Edward, Tang, Weiping, Bradner, James E., Schreiber, Stuart L., Duraisingh, Manoj T., Wirth, Dyann F., Clardy, Jon
Format: Artigo
Idioma:Inglês
Publicat: American Chemical Society 2009
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2669731/
https://ncbi.nlm.nih.gov/pubmed/19317450
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm801654y
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