Identification and validation of tetracyclic benzothiazepines as Plasmodium falciparum cytochrome bc(1) inhibitors

Here we report the discovery of tetracyclic benzothiazepines (BTZ) as highly potent and selective antimalarials along with the identification of the Plasmodium falciparum cytochrome bc(1) complex as the primary functional target of this novel compound class. Investigation of the structure activity r...

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Detalhes bibliográficos
Main Authors: Dong, Carolyn, Urgaonkar, Sameer, Cortese, Joseph F., Gamo, F. Javier, Garcia-Bustos, Jose F., Lafuente, Maria J., Patel, Vishal, Ross, Leila, Coleman, Bradley I., Derbyshire, Emily R., Clish, Clary B., Serrano, Adelfa E., Cromwell, Mandy, Barker, Robert H., Dvorin, Jeffrey D., Duraisingh, Manoj T., Wirth, Dyann F., Clardy, Jon, Mazitschek, Ralph
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3474356/
https://ncbi.nlm.nih.gov/pubmed/22195562
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2011.09.016
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