Structure-based design, synthesis, X-ray studies, and biological evaluation of novel HIV-1 protease inhibitors containing isophthalamide-derived P2-ligands

We describe the design, synthesis and biological evaluation of a series of novel HIV-1 protease inhibitors bearing isophthalamide derivatives as the P2–P3 ligands. We have investigated a range of acyclic and heterocyclic amides as the extended P2–P3 ligands. These inhibitors displayed good to excell...

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Detalhes bibliográficos
Publicado no:Bioorg Med Chem Lett
Main Authors: Ghosh, Arun K., Takayama, Jun, Kassekert, Luke A., Ella-Menye, Jean-Rene, Yashchuk, Sofiya, Agniswamy, Johnson, Wang, Yuan-Fang, Aoki, Manabu, Amano, Masayuki, Weber, Irene T., Mitsuya, Hiroaki
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4607586/
https://ncbi.nlm.nih.gov/pubmed/26096678
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2015.05.052
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