PK/PD Disconnect Observed with a Reversible Endothelial Lipase Inhibitor

द्वारा Hangeland, Jon J., Abell, Lynn M., Adam, Leonard P., Jiang, Ji, Friends, Todd J., Haque, Lauren E., Neels, James, Onorato, Joelle M., Chen, Alice Ye A., Taylor, David S., Yin, Xiaohong, Harrity, Thomas W., Basso, Michael D., Yang, Richard, Sleph, Paul G., Gordon, David A., Huang, Christine S., Wexler, Ruth R., Finlay, Heather J., Lawrence, R. Michael
में प्रकाशित ACS Med Chem Lett (2018)

Optimization of 1,2,4-Triazolopyridines as Inhibitors of Human 11β-Hydroxysteroid Dehydrogenase Type 1 (11β-HSD-1)

द्वारा Li, Jun, Kennedy, Lawrence J., Wang, Haixia, Li, James J., Walker, Steven J., Hong, Zhenqiu, O’Connor, Stephen P., Nayeem, Akbar, Camac, Daniel M., Morin, Paul E., Sheriff, Steven, Wang, Mengmeng, Harper, Timothy, Golla, Rajasree, Seethala, Ramakrishna, Harrity, Thomas, Ponticiello, Randolph P., Morgan, Nathan N., Taylor, Joseph R., Zebo, Rachel, Gordon, David A., Robl, Jeffrey A.
प्रकाशित 2014

11β-Hydroxysteroid Dehydrogenase Type 1 Gene Knockout Attenuates Atherosclerosis and In Vivo Foam Cell Formation in Hyperlipidemic apoE(−/−) Mice

द्वारा García, Ricardo A., Search, Debra J., Lupisella, John A., Ostrowski, Jacek, Guan, Bo, Chen, Jian, Yang, Wen-Pin, Truong, Amy, He, Aiqing, Zhang, Rongan, Yan, Mujing, Hellings, Samuel E., Gargalovic, Peter S., Ryan, Carol S., Watson, Linda M., Langish, Robert A., Shipkova, Petia A., Carson, Nancy L., Taylor, Joseph R., Yang, Richard, Psaltis, George C., Harrity, Thomas W., Robl, Jeffrey A., Gordon, David A.
प्रकाशित 2013

Discovery of Clinical Candidate BMS-823778 as an Inhibitor of Human 11β-Hydroxysteroid Dehydrogenase Type 1 (11β-HSD-1)

द्वारा Li, Jun, Kennedy, Lawrence J., Walker, Steven J., Wang, Haixia, Li, James J., Hong, Zhenqiu, O’Connor, Stephen P., Ye, Xiang-yang, Chen, Stephanie, Wu, Shung, Yoon, David S., Nayeem, Akbar, Camac, Daniel M., Ramamurthy, Vidhyashankar, Morin, Paul E., Sheriff, Steven, Wang, Mengmeng, Harper, Timothy W., Golla, Rajasree, Seethala, Ramakrishna, Harrity, Thomas, Ponticiello, Randolph P., Morgan, Nathan N., Taylor, Joseph R., Zebo, Rachel, Maxwell, Brad, Moulin, Frederick, Gordon, David A., Robl, Jeffrey A.
में प्रकाशित ACS Med Chem Lett (2018)

Discovery and Preclinical Evaluation of BMS-711939, an Oxybenzylglycine Based PPARα Selective Agonist

द्वारा Shi, Yan, Li, Jun, Kennedy, Lawrence J., Tao, Shiwei, Hernández, Andrés S., Lai, Zhi, Chen, Sean, Wong, Henry, Zhu, Juliang, Trehan, Ashok, Lim, Ngiap-Kie, Zhang, Huiping, Chen, Bang-Chi, Locke, Kenneth T., O’Malley, Kevin M., Zhang, Litao, Srivastava, Rai Ajit, Miao, Bowman, Meyers, Daniel S., Monshizadegan, Hossain, Search, Debra, Grimm, Denise, Zhang, Rongan, Harrity, Thomas, Kunselman, Lori K., Cap, Michael, Muckelbauer, Jodi, Chang, Chiehying, Krystek, Stanley R., Li, Yi-Xin, Hosagrahara, Vinayak, Zhang, Lisa, Kadiyala, Pathanjali, Xu, Carrie, Blanar, Michael A., Zahler, Robert, Mukherjee, Ranjan, Cheng, Peter T. W., Tino, Joseph A.
में प्रकाशित ACS Med Chem Lett (2016)