11β-Hydroxysteroid Dehydrogenase Type 1 Gene Knockout Attenuates Atherosclerosis and In Vivo Foam Cell Formation in Hyperlipidemic apoE(−/−) Mice

BACKGROUND: Chronic glucocorticoid excess has been linked to increased atherosclerosis and general cardiovascular risk in humans. The enzyme 11β-hydroxysteroid dehydrogenase type 1 (11βHSD1) increases active glucocorticoid levels within tissues by catalyzing the conversion of cortisone to cortisol....

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Detalhes bibliográficos
Main Authors: García, Ricardo A., Search, Debra J., Lupisella, John A., Ostrowski, Jacek, Guan, Bo, Chen, Jian, Yang, Wen-Pin, Truong, Amy, He, Aiqing, Zhang, Rongan, Yan, Mujing, Hellings, Samuel E., Gargalovic, Peter S., Ryan, Carol S., Watson, Linda M., Langish, Robert A., Shipkova, Petia A., Carson, Nancy L., Taylor, Joseph R., Yang, Richard, Psaltis, George C., Harrity, Thomas W., Robl, Jeffrey A., Gordon, David A.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3562192/
https://ncbi.nlm.nih.gov/pubmed/23383297
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0053192
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