Optimization of 1,2,4-Triazolopyridines as Inhibitors of Human 11β-Hydroxysteroid Dehydrogenase Type 1 (11β-HSD-1)

[Image: see text] Small alkyl groups and spirocyclic-aromatic rings directly attached to the left side and right side of the 1,2,4-triazolopyridines (TZP), respectively, were found to be potent and selective inhibitors of human 11β-hydroxysteroid dehydrogenase-type 1 (11β-HSD-1) enzyme. 3-(1-(4-Chlo...

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Detalhes bibliográficos
Main Authors: Li, Jun, Kennedy, Lawrence J., Wang, Haixia, Li, James J., Walker, Steven J., Hong, Zhenqiu, O’Connor, Stephen P., Nayeem, Akbar, Camac, Daniel M., Morin, Paul E., Sheriff, Steven, Wang, Mengmeng, Harper, Timothy, Golla, Rajasree, Seethala, Ramakrishna, Harrity, Thomas, Ponticiello, Randolph P., Morgan, Nathan N., Taylor, Joseph R., Zebo, Rachel, Gordon, David A., Robl, Jeffrey A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2014
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4094253/
https://ncbi.nlm.nih.gov/pubmed/25050169
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml500144h
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