Optimization of 1,2,4-Triazolopyridines as Inhibitors of Human 11β-Hydroxysteroid Dehydrogenase Type 1 (11β-HSD-1)

[Image: see text] Small alkyl groups and spirocyclic-aromatic rings directly attached to the left side and right side of the 1,2,4-triazolopyridines (TZP), respectively, were found to be potent and selective inhibitors of human 11β-hydroxysteroid dehydrogenase-type 1 (11β-HSD-1) enzyme. 3-(1-(4-Chlo...

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Auteurs principaux: Li, Jun, Kennedy, Lawrence J., Wang, Haixia, Li, James J., Walker, Steven J., Hong, Zhenqiu, O’Connor, Stephen P., Nayeem, Akbar, Camac, Daniel M., Morin, Paul E., Sheriff, Steven, Wang, Mengmeng, Harper, Timothy, Golla, Rajasree, Seethala, Ramakrishna, Harrity, Thomas, Ponticiello, Randolph P., Morgan, Nathan N., Taylor, Joseph R., Zebo, Rachel, Gordon, David A., Robl, Jeffrey A.
Format: Artigo
Langue:Inglês
Publié: American Chemical Society 2014
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4094253/
https://ncbi.nlm.nih.gov/pubmed/25050169
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml500144h
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