11β-Hydroxysteroid Dehydrogenase Type 1 (11β-HSD1) Inhibitors Still Improve Metabolic Phenotype in Male 11β-HSD1 Knockout Mice Suggesting Off-Target Mechanisms

The enzyme 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) is a target for novel type 2 diabetes and obesity therapies based on the premise that lowering of tissue glucocorticoids will have positive effects on body weight, glycemic control, and insulin sensitivity. An 11β-HSD1 inhibitor (compound...

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Detalhes bibliográficos
Main Authors: Harno, Erika, Cottrell, Elizabeth C., Yu, Alice, DeSchoolmeester, Joanne, Gutierrez, Pablo Morentin, Denn, Mark, Swales, John G., Goldberg, Fred W., Bohlooly-Y, Mohammad, Andersén, Harriet, Wild, Martin J., Turnbull, Andrew V., Leighton, Brendan, White, Anne
Formato: Artigo
Idioma:Inglês
Publicado em: Endocrine Society 2013
Assuntos:
Energy Balance-Obesity
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4192288/
https://ncbi.nlm.nih.gov/pubmed/24169553
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2013-1613
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