11β-Hydroxysteroid Dehydrogenase Type 1(11β-HSD1) mediates insulin resistance through JNK activation in adipocytes

Glucocorticoids are used to treat a number of human diseases but often lead to insulin resistance and metabolic syndrome. 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) is a key enzyme that catalyzes the intracellular conversion of cortisone to physiologically active cortisol. Despite the known...

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Publicado no:Sci Rep
Main Authors: Peng, Kesong, Pan, Yong, Li, Jieli, Khan, Zia, Fan, Mendi, Yin, Haimin, Tong, Chao, Zhao, Yunjie, Liang, Guang, Zheng, Chao
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5107914/
https://ncbi.nlm.nih.gov/pubmed/27841334
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep37160
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