Design, synthesis, and cytotoxic activity of novel 7-substituted camptothecin derivatives incorporating piperazinyl-sulfonylamidine moieties

In our continuing search for camptothecin (CPT)-derived antitumor drugs, novel 7-substituted CPT derivatives incorporating piperazinyl-sulfonylamidine moieties were designed, synthesized and evaluated for cytotoxicity against five tumor cell lines (A-549, MDA-MB-231, MCF-7, KB, and KB-VIN). All of t...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Bioorg Med Chem Lett
Main Authors: Yang, Cheng-Jie, Song, Zi-Long, Goto, Masuo, Liu, Ying-Qian, Hsieh, Kan-Yen, Morris-Natschke, Susan L., Zhao, Yong-Long, Zhang, Jun-Xiang, Lee, Kuo-Hsiung
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6421834/
https://ncbi.nlm.nih.gov/pubmed/28789891
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2017.07.078
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados