Design and Synthesis of Novel PEG-conjugated 20(S)-Camptothecin Sulfonylamidine Derivatives with Potent in vitro Antitumor Activity via Cu-Catalyzed Three-Component Reaction

In our continuing search for camptothecin (CPT)-derived antitumor drugs, novel structurally diverse PEG-based 20(S)-CPT sulfonylamidine derivatives were designed, synthesized via a Cu-multicomponent reaction (MCR), and evaluated for cytotoxicity against four human tumor cell lines (A-549, MDA-MB-231...

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Detalhes bibliográficos
Publicado no:Bioorg Med Chem Lett
Main Authors: Song, Zi-Long, Chen, Hai-Le, Wang, Yu-Han, Goto, Masuo, Gao, Wen-Jing, Cheng, Pi-Le, Morris-Natschke, Susan L., Liu, Ying-Qian, Zhu, Gao-Xiang, Wang, Mei-Juan, Lee, Kuo-Hsiung
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4768722/
https://ncbi.nlm.nih.gov/pubmed/25987370
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2015.04.060
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