Design, Synthesis, Mechanisms of Action, and Toxicity of Novel 20(S)-Sulfonylamidine Derivatives of Camptothecin as Potent Antitumor Agents

[Image: see text] Twelve novel 20-sulfonylamidine derivatives (9a–9l) of camptothecin (1) were synthesized via a Cu-catalyzed three-component reaction. They showed similar or superior cytotoxicity compared with that of irinotecan (3) against A-549, DU-145, KB, and multidrug-resistant (MDR) KBvin tum...

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Detaylı Bibliyografya
Asıl Yazarlar: Wang, Mei-Juan, Liu, Ying-Qian, Chang, Ling-Chu, Wang, Chih-Ya, Zhao, Yong-Long, Zhao, Xiao-Bo, Qian, Keduo, Nan, Xiang, Yang, Liu, Yang, Xiao-Ming, Hung, Hsin-Yi, Yang, Jai-Sing, Kuo, Daih-Huang, Goto, Masuo, Morris-Natschke, Susan L., Pan, Shiow-Lin, Teng, Che-Ming, Kuo, Sheng-Chu, Wu, Tian-Shung, Wu, Yang-Chang, Lee, Kuo-Hsiung
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Chemical Society 2014
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4111373/
https://ncbi.nlm.nih.gov/pubmed/25003995
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm5003588
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