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Design and synthesis of novel spin-labeled camptothecin derivatives as potent cytotoxic agents
In our continuing search for natural product-based spin-labeled antitumor drugs, 20 novel spin-labeled camptothecin derivatives were synthesized via a Cu-catalyzed one pot reaction and evaluated for cytotoxicity against four human tumor cell lines (A-549, MDA-MB-231, KB, and KBvin). Eighteen of the...
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| Publicado no: | Bioorg Med Chem |
|---|---|
| Main Authors: | , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4357344/ https://ncbi.nlm.nih.gov/pubmed/25438769 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2014.09.035 |
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