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Synthesis of Unsymmetrical Biphenyls as Potent Cytotoxic Agents
Twenty-six unsymmetrical biphenyls were synthesized and evaluated for cytotoxic activity against DU145, A547, KB and KB-Vin tumor cell lines. Three compounds 27, 35 and 40 showed very potent activity against the HTCL panel with an IC(50) value range of 0.04–3.23 µM. In addition, fourteen active comp...
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| Auteurs principaux: | , , , , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2008
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2577197/ https://ncbi.nlm.nih.gov/pubmed/18782668 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2008.08.050 |
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