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First Total Synthesis of Protoapigenone and its Analogs as Potent Cytotoxic Agents
Protoapigenone (1), isolated from Thelypteris torresiana, previously showed significant cytotoxic activity against five human cancer cell lines. In a continued structure-activity relationship study, the first total synthesis and modification of 1 were achieved. All synthesized compounds and related...
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| Main Authors: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2587018/ https://ncbi.nlm.nih.gov/pubmed/17622129 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm070363a |
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