Antitumor Agents. 271. Total Synthesis and Evaluation of Brazilein and Analogs as Anti-inflammatory and Cytotoxic Agents

The first total synthesis of the naturally occurring tetracyclic homoisoflavonoid brazilein (1) and 14 new analogs (1a–n) is reported. Target compounds and intermediates were assayed for anti-inflammatory effects on superoxide anion generation and elastase release by human neutrophils in response to...

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Bibliografiske detaljer
Main Authors: Yen, Chiao-Ting, Nakagawa-Goto, Kyoko, Hwang, Tsong-Long, Wu, Pei-Chi, Morris-Natschke, Susan L., Lai, Wan-Chun, Bastow, Kenneth F., Chang, Fang-Rong, Wu, Yang-Chang, Lee, Kuo-Hsiung
Format: Artigo
Sprog:Inglês
Udgivet: 2009
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2831747/
https://ncbi.nlm.nih.gov/pubmed/20036537
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2009.12.041
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