Design and synthesis of new 7-(N-substituted-methyl)-camptothecin derivatives as potent cytotoxic agents

A series of novel 7-(N-substituted-methyl)-camptothecin derivatives was designed, synthesized, and evaluated for in vitro cytotoxicity against four human tumor cell lines, A-549, MDA-MB-231, KB, and KBvin. All of the derivatives showed promising in vitro cytotoxic activity against the tested tumor c...

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Autores principales: Zhao, Xiao-Bo, Goto, Masuo, Song, Zi-Long, Morris-Natschke, Susan L., Zhao, Yu, Wu, Dan, Yang, Liu, Li, Shu-Gang, Liu, Ying-Qian, Zhu, Gao-Xiang, Wu, Xiao-Bing, Lee, Kuo-Hsiung
Formato: Artigo
Lenguaje:Inglês
Publicado: 2014
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4130764/
https://ncbi.nlm.nih.gov/pubmed/25008456
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2014.06.060
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