Design, Synthesis, Cytotoxic Activity and Molecular Docking Studies of New 20(S)-Sulfonylamidine Camptothecin Derivatives

In an ongoing investigation of 20-sulfonylamidine derivatives (9, YQL-9a) of camptothecin (1) as potential anticancer agents directly and selectively inhibiting topoisomerase (Topo) I, the sulfonylamidine pharmacophore was held constant, and a camptothecin derivatives with various substitution patte...

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Detalhes bibliográficos
Publicado no:Eur J Med Chem
Main Authors: Song, Zi-Long, Wang, Mei-Juan, Li, Lanlan, Wu, Dan, Wang, Yu-Han, Yan, Li-Ting, Morris-Natschke, Susan L., Liu, Ying-Qian, Zhao, Yong-Long, Wang, Chih-Ya, Liu, Huanxiang, Goto, Masuo, Liu, Heng, Zhu, Gao-Xiang, Lee, Kuo-Hsiung
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4834258/
https://ncbi.nlm.nih.gov/pubmed/26994847
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejmech.2016.02.070
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