Using Thioamides to Site-Specifically Interrogate the Dynamics of Hydrogen Bond Formation in β-Sheet Folding

Por Culik, Robert M., Jo, Hyunil, DeGrado, William F., Gai, Feng
Publicado em 2012

Selective Incorporation of Nitrile-Based Infrared Probes into Proteins via Cysteine Alkylation

Por Jo, Hyunil, Culik, Robert M., Korendovych, Ivan V., DeGrado, William F., Gai, Feng
Publicado em 2010

Assessment of Local Friction in Protein Folding Dynamics Using a Helix Cross-Linker

Por Markiewicz, Beatrice N., Jo, Hyunil, Culik, Robert M., DeGrado, William F., Gai, Feng
Publicado em 2013

Affinity of talin-1 for the β3-integrin cytosolic domain is modulated by its phospholipid bilayer environment

Por Moore, David T., Nygren, Patrik, Jo, Hyunil, Boesze-Battaglia, Kathleen, Bennett, Joel S., DeGrado, William F.
Publicado em 2012

Photoactivatable protein labeling by singlet oxygen mediated reactions

Por To, Tsz-Leung, Medzihradszky, Katalin F., Burlingame, Alma L., DeGrado, William F., Jo, Hyunil, Shu, Xiaokun
Publicado no Bioorg Med Chem Lett (2016)

Blue fluorescent amino acid for biological spectroscopy and microscopy

Por Hilaire, Mary Rose, Ahmed, Ismail A., Lin, Chun-Wei, Jo, Hyunil, DeGrado, William F., Gai, Feng
Publicado no Proc Natl Acad Sci U S A (2017)

The α(v)β(1) integrin plays a critical in vivo role in tissue fibrosis

Por Reed, Nilgun I., Jo, Hyunil, Chen, Chun, Tsujino, Kazuyuki, Arnold, Thomas D., DeGrado, William F., Sheppard, Dean
Publicado no Sci Transl Med (2015)

Structural Polymorphism of Alzheimer’s β-Amyloid Fibrils as Controlled by an E22 Switch: A Solid-State NMR Study

Por Elkins, Matthew R., Wang, Tuo, Nick, Mimi, Jo, Hyunil, Lemmin, Thomas, Prusiner, Stanley B., DeGrado, William F., Stöhr, Jan, Hong, Mei
Publicado no J Am Chem Soc (2016)

Infrared and Fluorescence Assessment of the Hydration Status of the Tryptophan Gate in Influenza A M2 Proton Channel

Por Markiewicz, Beatrice N., Lemmin, Thomas, Zhang, Wenkai, Ahmed, Ismail A., Jo, Hyunil, Fiorin, Giacomo, Troxler, Thomas, DeGrado, William F., Gai, Feng
Publicado no Phys Chem Chem Phys (2016)

Targeting integrin α(5)β(1) ameliorates severe airway hyperresponsiveness in experimental asthma

Por Sundaram, Aparna, Chen, Chun, Khalifeh-Soltani, Amin, Atakilit, Amha, Ren, Xin, Qiu, Wenli, Jo, Hyunil, DeGrado, William, Huang, Xiaozhu, Sheppard, Dean
Publicado no J Clin Invest (2016)

Development of α-Helical Calpain Probes by Mimicking a Natural Protein-Protein Interaction

Por Jo, Hyunil, Meinhardt, Nataline, Wu, Yibing, Kulkarni, Swapnil, Hu, Xiaozhen, Low, Kristin E., Davies, Peter L., DeGrado, William F., Greenbaum, Doron C.
Publicado em 2012

Exploring N-Arylsulfonyl-l-proline Scaffold as a Platform for Potent and Selective αvβ1 Integrin Inhibitors

Por Reed, Nilgun Isik, Tang, You-Zhi, McIntosh, Joel, Wu, Yibing, Molnar, Kathleen S., Civitavecchia, Annafelicia, Sheppard, Dean, DeGrado, William F., Jo, Hyunil
Publicado no ACS Med Chem Lett (2016)

Discovery of Novel Dual Inhibitors of the Wild-Type and the Most Prevalent Drug-Resistant Mutant, S31N, of the M2 Proton Channel from Influenza A Virus

Por Wang, Jizhou, Ma, Chunlong, Wang, Jun, Jo, Hyunil, Canturk, Belgin, Fiorin, Giacomo, Pinto, Lawrence H., Lamb, Robert A., Klein, Michael L., DeGrado, William F.
Publicado em 2013

Pharmacologic Blockade of αvβ1 Integrin Ameliorates Renal Failure and Fibrosis In Vivo

Por Chang, Yongen, Lau, Wei Ling, Jo, Hyunil, Tsujino, Kazuyuki, Gewin, Leslie, Reed, Nilgun Isik, Atakilit, Amha, Nunes, Ane Claudia Fernandes, DeGrado, William F., Sheppard, Dean
Publicado no J Am Soc Nephrol (2017)

Flipping in the Pore: Discovery of Dual Inhibitors That Bind in Different Orientations to the Wild-Type versus the Amantadine-Resistant S31N Mutant of the Influenza A Virus M2 Prot...

Por Wu, Yibing, Canturk, Belgin, Jo, Hyunil, Ma, Chunlong, Gianti, Eleonora, Klein, Michael L., Pinto, Lawrence H., Lamb, Robert A., Fiorin, Giacomo, Wang, Jun, DeGrado, William F.
Publicado no J Am Chem Soc (2014)

Stapled Voltage-Gated Calcium Channel (Ca(V)) α-Interaction Domain (AID) Peptides Act As Selective Protein–Protein Interaction Inhibitors of Ca(V) Function

Por Findeisen, Felix, Campiglio, Marta, Jo, Hyunil, Abderemane-Ali, Fayal, Rumpf, Christine H., Pope, Lianne, Rossen, Nathan D., Flucher, Bernhard E., DeGrado, William F., Minor, Daniel L.
Publicado no ACS Chem Neurosci (2017)

Altering the O(2)-Dependent Reactivity of de novo Due Ferri Proteins

Por Reig, Amanda J., Pires, Marcos M., Snyder, Rae Ana, Wu, Yibing, Jo, Hyunil, Kulp, Daniel W., Butch, Susan E., Calhoun, Jennifer R., Szyperski, Thomas, Solomon, Edward I., DeGrado, William F.
Publicado em 2012

Discovery of Potent Small-Molecule Inhibitors of Multidrug-Resistant Plasmodium falciparum Using a Novel Miniaturized High-Throughput Luciferase-Based Assay

Por Lucumi, Edinson, Darling, Claire, Jo, Hyunil, Napper, Andrew D., Chandramohanadas, Rajesh, Fisher, Nicholas, Shone, Alison E., Jing, Huiyan, Ward, Stephen A., Biagini, Giancarlo A., DeGrado, William F., Diamond, Scott L., Greenbaum, Doron C.
Publicado em 2010

Inhibition of Integrin α2β1 Ameliorates Glomerular Injury

Por Borza, Corina M., Su, Yan, Chen, Xiwu, Yu, Ling, Mont, Stacey, Chetyrkin, Sergei, Voziyan, Paul, Hudson, Billy G., Billings, Paul C., Jo, Hyunil, Bennett, Joel S., DeGrado, William F., Eckes, Beate, Zent, Roy, Pozzi, Ambra
Publicado em 2012

Platelet Factor 4 Activity against P. falciparum and Its Translation to Nonpeptidic Mimics as Antimalarials

Por Love, Melissa S., Millholland, Melanie G., Mishra, Satish, Kulkarni, Swapnil, Freeman, Katie B., Pan, Wenxi, Kavash, Robert W., Costanzo, Michael J., Jo, Hyunil, Daly, Thomas M., Williams, Dewight R., Kowalska, M. Anna, Bergman, Lawrence W., Poncz, Mortimer, DeGrado, William F., Sinnis, Photini, Scott, Richard W., Greenbaum, Doron C.
Publicado em 2012