Pharmacologic Blockade of αvβ1 Integrin Ameliorates Renal Failure and Fibrosis In Vivo

Activated fibroblasts are deemed the main executors of organ fibrosis. However, regulation of the pathologic functions of these cells in vivo is poorly understood. PDGF receptor β (PDGFRβ) is highly expressed in activated pericytes, a main source of fibroblasts. Studies using a PDGFRβ promoter–drive...

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Detalhes bibliográficos
Publicado no:J Am Soc Nephrol
Main Authors: Chang, Yongen, Lau, Wei Ling, Jo, Hyunil, Tsujino, Kazuyuki, Gewin, Leslie, Reed, Nilgun Isik, Atakilit, Amha, Nunes, Ane Claudia Fernandes, DeGrado, William F., Sheppard, Dean
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Nephrology 2017
Assuntos:
Brief Communications
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5491273/
https://ncbi.nlm.nih.gov/pubmed/28220032
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2015050585
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