Exploring N-Arylsulfonyl-l-proline Scaffold as a Platform for Potent and Selective αvβ1 Integrin Inhibitors

[Image: see text] One small molecule inhibitor of αvβ1 integrin, c8, shows antifibrotic effects in multiple in vivo mouse models. Here we synthesized c8 analogues and systematically investigate their structure–activity relationships (SAR) in αvβ1 integrin inhibition. N-Phenylsulfonyl-l-homoproline a...

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Publicat a:ACS Med Chem Lett
Autors principals: Reed, Nilgun Isik, Tang, You-Zhi, McIntosh, Joel, Wu, Yibing, Molnar, Kathleen S., Civitavecchia, Annafelicia, Sheppard, Dean, DeGrado, William F., Jo, Hyunil
Format: Artigo
Idioma:Inglês
Publicat: American Chemical Society 2016
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5066160/
https://ncbi.nlm.nih.gov/pubmed/27774126
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.6b00196
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